CAS No.: 84371-65-3 Mifepristone

Mifepristone
Molecular Formula: C29H35NO2
CAS No.: 84371-65-3
Purity: 99%
Synonyms: 11b-[p-(Dimethylamino)phenyl]-17b-hydroxy-17-(1-propynyl)estra-4, 9-dien-3-one
Molecular Weight: 429.60
Appearance: Light yellow crystalline powder
Application: A progesterone receptor antagonist with partial agonist activity


Mifepristone is an antioxidant and glucocorticoid receptor (GR) antagonist which has demonstrated the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes. It is also an inhibitor of the progesterone receptor. Mifepristone has been found to decrease basal bcl-2 messenger RNA levels in CA1 neural regions and the dentate gyrus. Experiments have shown that mifepristone potentially exhibits an inhibitory effect on embryo implantation via regulation of FAS and FAS-L apoptosis gene expression. Additionally, mifepristone displays anti-angiogenic characteristics via suppression of vascular endothelial factor (VEGF) production. Mifepristone may also prevent intracellular peroxide accumulation and cell death induced by hydrogen peroxide, glutamate, β -amyloid protein, or neurotoxins that have been associated with certain neurodegenerative disorders.


  Mifepristone
Molecular Formula: C29H35NO2
CAS No.: 84371-65-3
Purity: 99%
Synonyms: 11b-[p-(Dimethylamino)phenyl]-17b-hydroxy-17-(1-propynyl)estra-4, 9-dien-3-one
Molecular Weight: 429.60
Appearance: Light yellow crystalline powder
Application: A progesterone receptor antagonist with partial agonist activity


Mifepristone is an antioxidant and glucocorticoid receptor (GR) antagonist which has demonstrated the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes. It is also an inhibitor of the progesterone receptor. Mifepristone has been found to decrease basal bcl-2 messenger RNA levels in CA1 neural regions and the dentate gyrus. Experiments have shown that mifepristone potentially exhibits an inhibitory effect on embryo implantation via regulation of FAS and FAS-L apoptosis gene expression. Additionally, mifepristone displays anti-angiogenic characteristics via suppression of vascular endothelial factor (VEGF) production. Mifepristone may also prevent intracellular peroxide accumulation and cell death induced by hydrogen peroxide, glutamate, β -amyloid protein, or neurotoxins that have been associated with certain neurodegenerative disorders.


 

Antifungal Drugs

Antifungal drug: A drug used to treat fungal infections(antimicrobial drugs).

Examples of antifungal drugs include miconazole and clotrimazole.

An antifungal medication is a pharmaceutical fungicide used to treat and prevent mycoses such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually obtained by a doctor's prescription, but a few are available OTC (over-the-counter).

Antifungal Drugs,Griseofulvin Drugs,Clotrimazole Drugs

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