A new technology that uses the HIV virus for gene delivery will soon be researched. It will be easier to research and cultivate the production of transgenic animals. This technology includes the genes of other species. The report was first published in the journal Science. Scientists believe that this progress can make genetic studies cheaper and more effective, especially in the field of disease. Professor David Baltimore, a senior research fellow at the California Institute of Science and Technology, said: "This new method of making species other than rats is particularly exciting. Many people have already adopted this method." Genetically modified animals contain genes from other species, and It is critical for biomedical research. Gene delivery methods are usually aimed at the first stage of embryonic cell development, when organisms are the most plastic. Many technologies are currently very expensive, relatively inefficient, academically demanding and unachievable in many biological species. For decades, scientists have tried to use retroviruses, such as HIV-HIV, as a tool for gene delivery. Retroviruses can easily replicate their genetic material into the host's chromosomes. In theory, scientists may be allowed to avoid the complex surgical techniques required by other methods. However, the use of retroviruses to create transgenic animals has until now been considered impractical. Previously, when transgenic embryos were grown, this caused the germs to appear unresponsive or inactive, resulting in the inability to detect the expression of the transferred gene. Biologist Rudolf Jaenisch, a biologist at Cambridge University and founder of genetically modified science, said that this new technology solves the doubts of scientists who wanted to use retrovirus as a gene transfer vector for 20-30 years. This has never worked before. Researchers in California have used the fragment from HIV as a tool for transgenes in experiments. HIV is a retrovirus that is biologically more complex than its counterpart. Baltimore said in an interview: “Although everything is derived from HIV, these are not part of the disease.†Baltimore's team attaches the retroviral vector to the fluorescent aequorin gene and will Injection into single cell mouse embryos placed in a petri dish. Embryos are transplanted into female mice and cultivated under certain conditions. The fluorescing gene was highly expressed in about 80% of the mice, some of which had green paws, tails, and faces. The genes also inherited the offspring of the mice. Researchers also found that they can apply genes to specific types of scale tissues--such as muscle and immune cells--so long as the retrovirus vectors are coupled in proper sequence. Scientists believe that their transfer mechanism can be easily achieved in other animals. When the scientists performed the experiment in mice, which were recognized as animals that were difficult to genetically modify, the researchers found that 60% of the mice were transgenic. Jaenisch commented: "This has even opened the door to primate transgenes. This discovery has hidden many applications." Baltimore proposed that the new method can also work in birds, and that animals do not currently have genetic modification. People are satisfied with the method. Birds are actually worth studying, especially its nervous system. The study of bird tweets is very important, but no one has modified its genes. Scientists say that this method of using the virus will continue to improve, and will not replace other methods of genetically modified animals.
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