Hydrogels, which are known for their biomimetic properties, are the primary materials for biomedical applications such as drug delivery, stem cell therapy. Traditional hydrogels consist of synthetic polymers or natural biomolecules, often used as passive scaffolds for molecules or cells that do not completely cover dynamic signals involved in biological processes, such as cell/tissue development.
Photo-responsive hydrogels are characterized by controlled molecular or cellular behavior, high spatial and temporal precision, and small invasiveness. The main challenge for scientists to use light-responsive hydrogels instead of traditional hydrogels is how to effectively assemble these complex globular proteins into supramolecular structures while maintaining function.
Recently, scientists at the Hong Kong University of Science and Technology created a B12-dependent photo-sensing hydrogel under mild conditions by covalently splicing the photoreceptor C-terminal adenosylcobalamin binding domain (CarHC) protein. B12-dependent light-sensing hydrogel). This method of assembling stimulating-reactive protein directly into a hydrogel provides a versatile solution for the design of "smart" biomaterials, opening up tremendous opportunities for future biomaterial development.
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