Pharmaceutical Intermediate 99% Raw Powder Milrinone CAS 78415-72-2

• Model NO.: 78415-72-2
• Customized: Non-Customized
• Suitable for: Adult
• Purity: >99%
• CAS No: 78415-72-2
• MW: 211.22
• Appearance: White Powder
• Usage: Antidepressant, 5ht Reuptake Inhibitor
• Trademark: saichuang
• Specification: 1kg/bag
• HS Code: 3004909090

• Powder: Yes
• Certification: GMP, HSE, ISO 9001, USP, BP
• State: Solid
• Product Name: Milrinone
• Mf: C12h9n3o
• Einecs: 278-903-6
• Grade: Pharma Grade
• Delivery Time: 5-7 Days
• Transport Package: as Required
• Origin: Hongkong

Pharmaceutical Intermediate 99% Raw Powder Milrinone CAS 78415-72-2


Basic info:

Description

Milrinone is a medication used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility and decrease pulmonary vascular resistance. Milrinone also works to vasodilate which helps alleviate increased pressures (afterload) on the heart, thus improving its pumping action. 

Overall, milrinone supports ventricular functioning of the heart by decreasing the degradation of cAMP and thus increasing phosphorylation levels of many components in the heart that contribute to contractility and heart rate. In the short term milrinone has been deemed beneficial to those experiencing heart failure and an effective therapy to maintain heart function following cardiac surgeries. There is no evidence of any long term beneficial effects on survival.


Mechanism of action

Milrinone is a phosphodiesterase-3 inhibitor.This drug inhibits the action of phosphodiesterase-3 and thus prevents degradation of cAMP. With increased cAMP levels there is an increase in the activation of PKA. This PKA will phosphorylate many components of the cardiomyocyte such as calcium channels and components of the myofilaments. Phosphorylation of calcium channels permits an increase in calcium influx into the cell.

This increase in calcium influx results in increased contractility. PKA also phosphorylates potassium channels promoting their action. Potassium channels are responsible for repolarization of the cardiomyocytes therefore increasing the rate at which cells can depolarize and generate contraction. PKA also phosphorylates components on myofilaments allowing actin and myosin to interact more easily and thus increasing contractility and the inotropic state of the heart. Milrinone allows stimulation of cardiac function independently of β-adrenergic receptors which appear to be down-regulated in those with heart failure.


Advantages:

1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥99%
4)We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3)High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
 


 

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