99% Purity New Sarms Gw0742 Gw610742 CAS317318-84-6 for Muscle Growth

Product Name:GW0742
Synonyms: GW610742
CAS:317318-84-6
MF:C21H17F4NO3S2
MW:471.49
Product Categories:All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Inhibitor
Mol File: 317318-84-6.mol

GW0742 / GW610742 Description:

GW0742, also known as GW610742, is a PPARδ/β agonist. GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons. GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. GW0742 has direct protective effects on right heart hypertrophy.GW0742 may enhance lipid metabolism in heart both in vivo and in vitro.

 

GW0742 / GW610742 Biological Activity:

GW0742 / GW610742 is a potent and highly selective PPARδ agonist. EC50 values are 1nM, 1.1μM and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively.
GW0742 is a synthetic high affinity PPAR β/δ agonist, and its possible role in preventing the advance of inflammatory and apoptotic processes induced by bleomycin, that long-term leads to the appearance of pulmonary fibrosis. Our data showed that GW0742-treatment (0.3 mg/Kg, 10 percent DMSO, i.p.) has therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters detected by measurement of:cytokine production; leukocyte accumulation, indirectly measured as decrease of myeloperoxidase (MPO) activity; IkBα degradation and NF-kB nuclear translocation; ERK phosphorylation; stress oxidative by NO formation due to iNOS expression; nitrotyrosine and PAR localization; the degree of apoptosis, evaluated by Bax and Bcl-2 balance, FAS ligand expression and TUNEL staining. Taken together, our results clearly show that GW0742 reduces the lung injury and inflammation due to the intratracheal BLEO--instillation in mice.  


FAQ:

1)Location & Working Hours
We are an International source locate in China.
I will answer emails from Monday to Saturday, 8:30 am to 18:00 pm (GMT+8)


2)How long does it takes to get back a response from you?
You should receive a response in less than 24 hours.


3)How do I make an order?
When you choosed the products, please email me, and I will quote for you, if you are satisfied with it, then pay for it, the parcle will be sent for you as soon as possible.


4)How to track my order?
 After I ship your order and have the tracking number, you will receive an email notification. All tracking numbers I provide can be tracked at http://www.17track.net/en. Or you can ask me for helping you track it too.


5)How long does the whole process take, from making an order till receiving the package?
The package will be prepared within 1 working day after payment received and be sent out within 72 hours. 
The delivery time depends on the shipping situation and customs. 
The shipping time will not more than 15 working days at most.


6)How about  the shipping cost?
The shipping cost is for the whole order. No matter how many different items and quantity in one orders. The shipping cost will be charged only once.


7)Is there a minimum order?
For raw powder: MOQ is 10g
For oil liquid: MOQ is 50ml
For peptide vial: MOQ is 10 vials


8)Reship Policy
To U.S. We reship for free twice if your package gets seized. 
To other countries we reship for free once if your package gets seized. 
If you choose not to reship or the resent package failed to go through again, no refund will be made.


9)Payment Ways
We accept Bank Transfer(T/T ), Western Union, Moneygram, Bitcoin.
*** The Bitboin is a little special for us, our Bitcoin account is always changing, once I gave you the account number, please pay for it at once.  


10)Refund policy
Our company has a 2 reship policy all foreign countries in case of a seizure.
**We are not responsible if you throw away your products because you cannot find them in our disguised package. If you cannot find your products please email me and I will tell you where to find them.

More Products:
  Product Name:GW0742
Synonyms: GW610742
CAS:317318-84-6
MF:C21H17F4NO3S2
MW:471.49
Product Categories:All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Inhibitor
Mol File: 317318-84-6.mol

GW0742 / GW610742 Description:

GW0742, also known as GW610742, is a PPARδ/β agonist. GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons. GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. GW0742 has direct protective effects on right heart hypertrophy.GW0742 may enhance lipid metabolism in heart both in vivo and in vitro.

 

GW0742 / GW610742 Biological Activity:

GW0742 / GW610742 is a potent and highly selective PPARδ agonist. EC50 values are 1nM, 1.1μM and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively.
GW0742 is a synthetic high affinity PPAR β/δ agonist, and its possible role in preventing the advance of inflammatory and apoptotic processes induced by bleomycin, that long-term leads to the appearance of pulmonary fibrosis. Our data showed that GW0742-treatment (0.3 mg/Kg, 10 percent DMSO, i.p.) has therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters detected by measurement of:cytokine production; leukocyte accumulation, indirectly measured as decrease of myeloperoxidase (MPO) activity; IkBα degradation and NF-kB nuclear translocation; ERK phosphorylation; stress oxidative by NO formation due to iNOS expression; nitrotyrosine and PAR localization; the degree of apoptosis, evaluated by Bax and Bcl-2 balance, FAS ligand expression and TUNEL staining. Taken together, our results clearly show that GW0742 reduces the lung injury and inflammation due to the intratracheal BLEO--instillation in mice.  


FAQ:

1)Location & Working Hours
We are an International source locate in China.
I will answer emails from Monday to Saturday, 8:30 am to 18:00 pm (GMT+8)


2)How long does it takes to get back a response from you?
You should receive a response in less than 24 hours.


3)How do I make an order?
When you choosed the products, please email me, and I will quote for you, if you are satisfied with it, then pay for it, the parcle will be sent for you as soon as possible.


4)How to track my order?
 After I ship your order and have the tracking number, you will receive an email notification. All tracking numbers I provide can be tracked at http://www.17track.net/en. Or you can ask me for helping you track it too.


5)How long does the whole process take, from making an order till receiving the package?
The package will be prepared within 1 working day after payment received and be sent out within 72 hours. 
The delivery time depends on the shipping situation and customs. 
The shipping time will not more than 15 working days at most.


6)How about  the shipping cost?
The shipping cost is for the whole order. No matter how many different items and quantity in one orders. The shipping cost will be charged only once.


7)Is there a minimum order?
For raw powder: MOQ is 10g
For oil liquid: MOQ is 50ml
For peptide vial: MOQ is 10 vials


8)Reship Policy
To U.S. We reship for free twice if your package gets seized. 
To other countries we reship for free once if your package gets seized. 
If you choose not to reship or the resent package failed to go through again, no refund will be made.


9)Payment Ways
We accept Bank Transfer(T/T ), Western Union, Moneygram, Bitcoin.
*** The Bitboin is a little special for us, our Bitcoin account is always changing, once I gave you the account number, please pay for it at once.  


10)Refund policy
Our company has a 2 reship policy all foreign countries in case of a seizure.
**We are not responsible if you throw away your products because you cannot find them in our disguised package. If you cannot find your products please email me and I will tell you where to find them.

More Products:
 

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