Release date: 2018-02-02
Recently, researchers from Osaka University revealed the effect of subcellular localization of Arid5a on the inflammatory response. Previously, we have known that the entry of this protein into the nucleus promotes the immune response, while localization in the cytoplasm blocks the inflammatory response.
Tadamitsu Kishimoto, a professor from the Center for Immunological Frontier Research at Osaka University, and others found the subcellular localization of Arid5a to regulate the inflammatory response. In this study, they found that Arid5 is transported from the nucleus to the cytoplasm under inflammatory signals; in addition, a protein called bimax can inhibit cNLS-dependent by producing high-affinity interactions with the NLS sequence of importin-a. Into nuclear behavior. In addition, LRMomycin B, an inhibitor of CRM1, was also able to inhibit the nucleation of Arid5a under LPS stimulation.
Macrophages can stimulate other immune cells to clear pathogens by secreting inflammatory factors. However, an excessive inflammatory response can lead to shock or autoimmune diseases. Therefore, how to regulate the intensity of the inflammatory response becomes very important. The researchers focused on the regulation of IL-6 mRNA by Arid5a and Regnase-1. Previous studies have shown that Arid5a can bind to the 3'UTR region of IL-6 mRNA, thereby inhibiting Regnase-1 mediated RNA degradation.
In addition, the level of inflammatory factor production in Arid5a-deficient mice was significantly down-regulated, and the shock response was also highly tolerated. Although the role of Arid5a in immune regulation is important, it is not clear how the subcellular of Arid5a will regulate immune responses.
In this study, the authors found that Arid5a produced a nuclear transport process under the action of LPS stimulation. Since blocking the export of Arid5a can inhibit the production of IL-6, the authors believe that future related research can find new targets for treating Xiuhe or ladder immune diseases.
Source: Bio Valley
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