Causes and solutions for discoloration of traditional Chinese medicine sugar-coated tablets
In the process of drug storage, traditional Chinese medicine sugar-coated tablets have surface spots, fading or cream, blackening, etc.
Image, the reasons and solutions for its occurrence are as follows.
First of all, wetness is one of the main causes of discoloration of sugar coatings. Exudation of water inside the sugar-coated tablet or its surface adsorption
The moisture can destroy the color coat layer.
Traditional Chinese medicine tablets are concentrated dosage forms, which are used to improve the curative effect and produce into extracts or dry extract tablets.
Wide range, high rate of paste, low cost and more use of extract. But the extract contains a lot of starch during the extraction process.
A hygroscopic component such as sugar, mucilage or inorganic salt, which is easily absorbed into the air after being made into a sugar-coated tablet.
Taking the process, the water extraction method or the alcohol extraction method is used to remove sugar, mucus, gum, etc. from the ingredients.
Hygroscopic ingredient. In addition, syrup is often used as a binder and coating material in the tablet production process, and the syrup is heated.
In the process, due to the long time or under the action of acid, the invert sugar content can be increased, and the invert sugar is also strong.
Moisture absorption, so in the process of tanning syrup, it is better to boil for 5 minutes to avoid excessive heating time.
Lead to an increase in invert sugar content.
If the core of the tablet itself has a large water content, the water is easily oozing out during storage, and should be strictly controlled during the preparation process.
The moisture in the tablet core should generally not exceed 5% , and the layers are dried during the coating process to control the water content. If
In the coating process, the gelatin hydrolysis of the barrier layer or the barrier layer is neglected, and the coating is not well polished, so that the coating is coated.
The moisture in the process can not be well baked, so that the water content of the sugar-coated tablet itself is too large, which can reduce the moisture-proof performance of the film.
Causes discoloration of the sugar-coated tablets. Therefore, according to the situation, choose the appropriate raw materials, wrap the isolation layer, pay attention to the quality of lighting
Control, the layer should be dry when the sugar coating. If the environment in which the film is stored is damp and the moisture resistance of the packaging material is not good,
The seal is not strict, and it is easy to cause the film to absorb moisture and discolor. Therefore, we should choose packaging materials with good moisture resistance and seal them tightly.
A moisture absorbent such as silica gel is placed in a dense container or in a package.
Secondly, light, humidity, pH , and volatile components can cause discoloration of the sugar-coated tablets, so in actual work.
Should pay attention. The film should be stored at a low temperature, dry and protected from light; reduce the contact of the tablet with the acid-base drug;
UV absorbers and visible light blockers may be added to the material to reduce or avoid the effect of light on the film.
As for the effect on volatile components, β -cyclodextrin inclusion or microencapsulation of volatile oils may be used.
Ingredients, thereby blocking the contact of the volatile oil with the surrounding environment, reducing the influence of humidity, allowing the volatile oil to be retained, increasing
Add drug stability to prevent extravasation of volatile oil components.
In short, there are many reasons for the discoloration of traditional Chinese medicine sugar-coated tablets, which should be paid attention to in actual work and have needles.
Sexually solved, so that the quality of traditional Chinese sugar coated tablets is guaranteed.
If you want to know more  For information on sugar-coated tablets , please visit our company : http://www. / or direct pharmaceutical technology department : <> consulting, our factory will provide you with more professional services.
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