Mark Roberts and Michelle Wood
Waters Corporation MS Technology Center (Manchester, UK)
Introduction <br> toxicology screening laboratories need a wide range of detection techniques in complex biological matrices highly toxic substances, such as living body sample and autopsy samples and the like. Two alternative toxicology screening methods were developed previously, both using the ACQUITY UPLC System and ACQUITY® TQD 1-3 . These two complementary methods allows users to take full advantage of the strengths and targeted MRM acquisition method of screening high-sensitivity full-scan data 4.
These methods have been successfully applied in more than 100 laboratories around the world, including laboratories with little or no experience in LC/MS. With the advent of next-generation instruments that provide better functionality and performance, people are beginning to focus on how to apply these powerful and sophisticated screening methods to new systems. This application note provides an initial evaluation of the suitability of the two existing screening methods for the ACQUITYUPLC I-Class System and the Xevo TQD Mass Spectrometer.
The objective of this study was to evaluate the usefulness of the ACQUITY UPLC® I-Class System and Xevo® TQD MS in forensic toxicology screening, as well as to evaluate existing chromatographic methods in conjunction with existing full-scan MS and MRM methods 1-3 in this Applicability on the new platform.
Waters Solutions
ACQUITY UPLC I-Class System
Xevo TQD mass spectrometer
RADARTM technology
PIC® scan
ACQUITY UPLC HSS C18 Column
Waters® Full Recycling Vial
Application advantages <br> more comprehensive toxicological screening platform using the latest equipment and two complementary methods. ACQUITY UPLC I-Class System and Xevo TQD MS:
â– A targeted MRM method with excellent sensitivity and selectivity for screening 178 important analytes with two ion pairs for each compound â– A full-scan MS method with over 950 toxic libraries, users can Easily add data to the library
To download the full application note, please click: http://?cid=511436&lid=134727525&locale=zh_CN
Pressure Relief Valve,Stainless Steel Constant Pressure Adjust Valve,Sanitary Stainless Steel Adjust Valve,Hygienic Constant Pressure Adjust Valve
Wenzhou Gaoya Light Industry Machinery Co.,ltd. , https://www.hongyafitting.com