New research: supplementing specific intestinal bacteria to treat food allergies
July 02, 2019 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Xinhua News Agency, Beijing, July 2 - A study published in the journal Nature Medicine recently showed that food allergies are related to intestinal microbial composition, and certain bacteria in the intestine can protect humans from food allergies. Experiments have shown that some specific bacteria in the intestine can reverse the food allergy symptoms in mice.
In recent years, the global incidence of food allergies has been rising. In the United States alone, on average, one person is sent to the emergency room every 3 minutes due to food allergies. Currently, it relies mainly on staying away from allergens to avoid the disease.
Lynn Buli, a co-author of the new study and a pathologist in the Brigham Gynecology Hospital in the United States, said the study "will represent a dramatic change in the treatment of food allergies."
Researchers at Brigham Gynecology Hospital and Boston Children's Hospital in the United States first collected 56 stool-infant infants and 98 non-allergic healthy infants, and collected their stool samples regularly. The differences in microbial species in the sample identify the specific strains that protect infants from food allergies from hundreds of gut bacteria.
On this basis, the researchers developed two "bacterial formulas" with protective effects, each consisting of 5 to 6 Clostridium or Bacteroides, all from the intestines of healthy infants. Animal experiments have shown that oral administration of any "formulation" to mice that are allergic to eggs can inhibit their allergic reactions, while oral administration of other types of intestinal bacteria does not achieve the same effect.
To clarify the pathological causes of allergies, the researchers also observed the immune system of humans and mice. They found that the above-mentioned "bacterial formula" can target two important immune pathways and stimulate specific regulatory T cells. The state of sex T cells enhances the tolerance of humans and mice to allergens.
Researchers believe that understanding allergen-related microbes and their targets can help find better allergies and treatments. Especially for food allergies, this research is expected to develop into a reliable treatment that will be used in human patients in the future.
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