Aseptic filling is a new type of packaging that is carried out in a sterile environment and has many applications in terms of fill size, bottle type and volume. Aseptic filling techniques and equipment play an important role in the pharmaceutical industry, especially in the biopharmaceutical industry.
As the final step in the production process, filling is extremely important to ensure the safety and efficacy of biopharmaceuticals. As the biological product stock is filled into the pharmaceutical packaging material in a sterile environment, and then labeled and packaged into finished pharmaceutical products, ensuring sterility is a key.
In addition, aseptic filling technology adopts normal temperature filling, which can save energy consumption compared with other hot filling methods, and has lower wall thickness requirements for packaging PET bottles, reducing bottle weight and reducing cost. . Therefore, aseptic filling is an advantageous choice for pharmaceutical companies.
As a carrier of aseptic filling technology, biopharmaceuticals are increasingly demanding aseptic filling equipment, and many biopharmaceutical companies are looking for high-tech aseptic filling equipment and systems to meet production needs.
In order to meet high demand, aseptic filling equipment companies have introduced robotics into aseptic filling equipment and systems. For example, some equipment companies have realized the dynamic filling of the intelligent robot aseptic filling system, which has changed the pollution risk caused by the artificial operation of the aseptic workshop.
Specifically, the robot has stable performance, no human intervention, no cross-contamination, can save floor space, and can reduce environmental and labor costs.
“Our robot is highly intelligent and capable of self-detecting, diagnosing and processing.†Technicians say there is also a high space utilization that can perform multiple functions in a limited space. In addition, modularity is also a feature that can be easily and quickly expanded to suit different production needs.
Equipment companies have also studied a glove-free isolation and redesigned the aseptic filling process to increase the flexibility of multi-product manufacturing. The so-called "gloveless" is actually an isolation device because it has no glove holes, the operator can intervene in the production process through the glove holes, and the robot performs all operations in these systems.
“By integrating the filling and handling robots in a gloveless isolation device, the risk of the product is much lower through particle generation or human intervention.†The designer introduced that the vision system and automated environmental monitoring support a repeatable, error-free The process is a strong guarantee of the safety of biopharmaceuticals.
In addition, whether the object of aseptic filling is a vial, syringe or cartridge, the handling and filling are the same, providing a highly repeatable process. With the closure and integration of vials, industry-standard stoppers are also used. These seals produce less particles and reduce the risk of contaminating the drug compared to conventional aluminum caps.
The technology of robots in aseptic filling equipment and systems has gradually upgraded. Some equipment companies have reached advanced levels in terms of project establishment, research and development programs, technical standards, and manufacturing levels. Some of the results have achieved good industrialization. And participate in international competition.
With the wide application of robots in aseptic filling equipment and systems, and even in the pharmaceutical equipment industry, pharmaceutical production will become more convenient and faster, and the pharmaceutical production environment will be more secure, while the efficacy and safety of drugs will be more effective. Reliability will also be an additional layer of insurance.
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