Release date: 2016-06-21
The researchers unraveled the secrets of our ancient immune system, a major scientific advance that could help scientists and clinicians around the world fight disease.
An international research team, including researchers at the University of Queensland, identified interactions between several immune system signaling pathways that could improve treatment for diseases such as inflammatory bowel disease (IBD). The research was published in the journal Science.
Leading the research is Professor Claudia Kemper, who is based at King's College London and the National Institutes of Health in the United Kingdom.
Professor Matt Cooper of the University of Queensland Institute for Molecular Biosciences (IMB) said that the immune system consists essentially of two parts: the adaptive immune system, which produces antibodies against infection; and an ancient signaling pathway: the natural immune system.
Professor Cooper said: "Innate immunity is so old that it extends to frogs, fish and even insects. It prevents us from getting infected and drives many inflammatory diseases. Therefore, in one case it prevents pathogen infection. We let us survive, but if it goes wrong, we suffer from diseases such as arthritis, multiple sclerosis and colitis. Researchers have always believed that the key components of these signaling pathways work alone, but our research team found that they can communicate And work together."
This finding may have important implications for the treatment of numerous autoimmune and inflammatory diseases.
Professor Cooper said: "In colitis-like diseases, inflammation occurs when the immune system is inappropriately activated, causing symptoms such as pain, diarrhea, fever, and weight loss. Current treatments are not always effective, and this may Because they only block one of the key signaling pathways, inflammation can still occur through another signaling pathway."
Professor Cooper and this international research team have developed two small molecules that each block a single signaling pathway. “We have tested these molecules and the results show that both administrations reduce inflammation. This work is still in its infancy, but we hope that ongoing research will lead to more effective therapies to treat millions of inflammatory bowels Sick patient."
Source: Biopass
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