Release date: 2014-05-07
On the 5th, US and Chinese researchers reported in the Proceedings of the National Academy of Sciences (PNAS) that they developed a non-invasive prenatal diagnostic method based on a semiconductor chip sequencer that can detect whether a fetus has a Down according to a blood sample from a pregnant woman. A congenital defect associated with chromosomal abnormalities such as the syndrome.
For pregnant women who need to undergo chromosomal abnormalities, traditional methods of amniocentesis or chorionic villus sampling are used, mostly in the 12 weeks of pregnancy. These interventional methods have two major drawbacks: First, they take a long time and take 2 weeks to 3 weeks to produce results. Second, the needle has less than 1% chance of being tied to the fetus, which may cause infection or even miscarriage.
The new diagnostic method developed by the University of California, San Diego, Guangzhou Medical University, Guangdong Maternal and Child Health Hospital and Guangzhou Aijian Biotechnology Co., Ltd. is based on a new high-throughput sequencing technology that allows only 2 ml of blood samples from pregnant women to be diagnosed. Congenital defects associated with chromosomal abnormalities, including the most common Down's syndrome, Edward's syndrome, which causes multiple abnormalities in the body and organs.
This high-throughput sequencing technology enables sequencing of hundreds of thousands to millions of DNAs (deoxyribonucleic acids) at a time. Professor Zhang Kang, the head of the study and director of the Institute of Genetic Medicine at the University of California, San Diego, said that the new diagnostic method is fast and can advance the diagnosis to the 9th week of pregnancy. The results will be 4 days, and the accuracy is very high. .
Zhang Kang said that the sequencing instrument used is based on a semiconductor chip, requiring only 15 samples per job. The sequencing time is only 2.5 hours. All tests can be completed directly by the hospital, which can improve the diagnosis speed and reduce the detection cost.
Zhang Kang also believes that with the increasing number of older mothers, the probability of birth defects in newborns is on the rise. The above new technology can accurately detect fetal chromosomal defects by using a small amount of peripheral blood from the mother, which helps to reduce the burden of birth defects on society and the family.
Original search:
Can Liao, Ai-hua Yin, Chun-fang Peng, Fang Fu, Jie-xia Yang, Ru Li, Yang-yi Chen, Dong-hong Luo, Yong-ling Zhang, Yan-mei Ou, Jian Li, Jing Wu, Ming-qin Mai, Rui Hou, Frances Wu, Hongrong Luo, Dong-zhi Li, Hai-liang Liu, Xiao-zhuang Zhang, and Kang Zhang. Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing . PNAS, May 5, 2014; Doi: 10.1073/pnas.1321997111
Source: Bio 360
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