Brain tumor can cause T lymphocytes to be trapped in the epiphysis
August 30, 2018 Source: Science and Technology Daily Author: Chen Chao
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];A joint study between Osaka University in Japan and Harvard University in the United States found that when tumors are present in the brain, the T lymphocytes needed to destroy the tumor are in a special state and cannot be released.
Studies have found that lymphocytes in peripheral blood of brain tumor mice and polymorphic glioblastoma patients are decreasing, but T lymphocytes in the callus are increasing. The reason for this phenomenon is that the expression of the S1P1 molecule on the T lymphocytes is significantly reduced (induced internalization), thereby causing the T lymphocytes to be unable to be released from the callus.
The study showed that if there is a tumor in the brain, the pattern of action of systemic T lymphocytes will change. If it is possible to find a treatment method for smoothly inducing T lymphocytes trapped in the epiphysis to the tumor environment, it is expected to improve the sensitivity to immunotherapy.
(Source of this column: Japan Science and Technology Promotion Agency: Chen Hao, reporter of the newspaper in Japan)
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