Recently, researchers from Brigham and Women's Hospital discovered two potential drug targets for the treatment of arterial diseases (such as atherosclerosis). By using proteomics to screen a large number of molecules, the researchers identified two The PARP family proteins: PARP9 and PARP14, which may act as regulators of macrophage activation, and the activation of macrophages is directly related to the occurrence of arterial disease. Related studies are published in the international journal Nature Communications.
Although the activation mechanism of macrophages has not yet been fully elucidated, previous studies have shown that macrophages play an important role in the development of atherosclerosis and its thrombotic complications. In this article, the researcher Dr. Masanori Aikawa and colleagues Atherosclerosis has been studied at the protein level to determine which molecule is involved in the regulation of macrophages.
Finally, the researchers locked their eyes on two proteins, which silenced the expression of each gene in macrophages and found that inhibition of PARP14 might increase macrophage expression, while inhibition of PARP9 would have the opposite effect. . Researchers hope that this hypothesis-based approach can simplify the long process of drug development; they also use a systematic approach, which depends on network analysis, which can help predict which pathway is likely The effects studied are controlled so that researchers can prioritize these pathways.
Next, researcher Aikawa and colleagues plan to continue their in-depth research to develop targeted therapies for the treatment of atherosclerosis and related diseases. Aikawa said that the activation of macrophages not only plays an important role in the pathogenesis of arterial diseases, but also is important for the study of a variety of inflammatory diseases and autoimmune diseases; the results of this study may provide us with important clues. Elucidation of the pathogenesis of atherosclerosis-related diseases and help develop more new therapies.
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