The pharmacological effects of evening primrose oil
1. Hypolipidemic and anti-atherosclerotic effects:
Evening primrose oil 5ml/kg can reduce the increase of serum total cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol in rats induced by high-fat diet, and can significantly increase the level of high-density lipoprotein cholesterol. . Rabbits fed with cholesterol and lard formed hyperlipidemia and atherosclerosis, evening primrose oil 0.1-0.3ml/kg gavage for 8 weeks; evening primrose oil fatty acid sodium salt 4.1g/kg, continuous irrigation In the stomach for 150 days, the formation of aortic plaques in animals was significantly reduced, and the inhibitory rate of evening primrose oil reached 47.6%-73.5%.
2. Weight loss: Evening primrose oil 0.3-1ml/kg, gavage for 8 weeks, can prevent hypothalamic obesity caused by subcutaneous injection of large doses of sodium glutamate (3mg/g body weight). Reduce triacylglycerol in animal blood and increase high-density lipoprotein cholesterol; inhibit the increase of adipocytes in glutamate sodium mice, thicken intestinal villi, and thus regulate gastrointestinal absorption and reduce body fat accumulation. effect.
3. Anti-fatty liver effect: evening primrose oil 0.3 ml/kg, and its 5% sodium salt 2 ml/kg and 5% sodium salt 6 ml/kg gavage on ethionine-induced rat fatty liver, evening primrose oil and Sodium salts have a good anti-fatty liver effect. Significantly reduce the content of triglyceride in fatty liver and inhibit the occurrence of fatty liver.
4. Anti-arrhythmic effects: Evening primrose oil and its sodium salt have significant preventive and therapeutic effects on aconitine-induced arrhythmias in rats, musculin G-induced arrhythmias in guinea pigs, and cesium chloride-induced arrhythmias in rabbits. The effect of arsenic chloride induced arrhythmia is most prominent.
5. Anti-inflammatory effect: evening primrose oil significantly inhibits inflammation caused by various inflammatory agents, evening primrose oil 2-4 ml/kg gavage mice ear swelling caused by xylene, for normal rats and adrenal gland rats Carrageenan and histamine, prostaglandin E2 (PGE2), blanch, formaldehyde, nystatin, etc. caused by foot swelling, have significant inhibitory effect. Inhibition of PGE release and inflammation of PGE and histamine, inhibition of bradykinin release, and stabilization of lysosomal membranes. Its anti-inflammatory effect is not through the excitement of the pituitary-adrenocortical system. It may be through inhibition of mediator release and inflammation, exudation, leukocyte chemotaxis, and connective tissue hyperplasia during inflammation.
6. Other effects: Evening primrose oil can prevent platelet aggregation and prevent thrombosis. When the final concentration of evening primrose oil is 1.80 μl/ml and 2.7 μl/ml, rabbit platelets induced by adenosine diphosphate (ADP) are used. The inhibition rate of aggregation was 41.8%±6.9% and 50.0±6.3%, respectively. It has a significant inhibitory effect on lipid peroxidation in mice liver; it can significantly enhance the activity of catalase in mice blood. Evening primrose oil 0.8g/kg, gavage once a day for 90 consecutive days can reduce the urinary protein in rats with chronic renal failure, improve urinary protein selectivity, increase blood-muscle phenol levels, pathological changes light. These changes are consistent with decreased levels of blood cholesterol and elevated levels of prostaglandin E2 and 6-keto-prostaglandin F1α in renal tissue.
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