Pharmacokinetics
Borneol is easily absorbed through mucous membranes and subcutaneous tissue and is eliminated from the body when combined with glucuronic acid in vivo. 3H-borneol 1μCi / (g body weight) gavage mice can be quickly absorbed through the intestinal mucosa, 5 minutes can pass through the blood-brain barrier, and the central nervous system has a higher concentration and longer residence time, its opening effect may be Related to it. Borneol can maintain a higher plasma concentration in the blood for a longer period of time, and is eliminated quickly by the liver and kidney, and it is not easy to accumulate. 3H-borneol 2.6μCi / mouse intravenous distribution half-life of 2.8min, mainly distributed heart, lung, liver, kidney and so on. 3.5μCi/gavage alone, half-absorption was 0.157 hours, absorption coefficient was 0.25, indicating poor bioavailability; the elimination half-life was 5.3 hours and it was not easy to accumulate.
Resin processed products, or the crystals of Dipterocarpaceae trunks that have been distilled and cooled, are called "Dragon Blephron Tablets," also known as "Mei." The sublimated material of the leaf of the Asteraceae (Ayurveda) Blumea balsamifera DC of Asteraceae, a perennial herb, has been processed and troweled, and is referred to as “Aliceâ€. Now more use of turpentine, camphor, etc., by chemical synthesis, known as "mechanical borneol." The borneol product must be stored in a cool place and sealed. Used for powdering.
A kind of trick. Molecular formula C10H18O. Also known as borneol or 2-sterol. White translucent hexagonal crystal, like the smell of camphor. Right borneol tablets are leafy or hexagonal platelet crystals; melting point 208°C, boiling point 212°C, relative density 1.011 (20/4°C), specific rotation +37.7 (ethanol); soluble in ethanol, ether and benzene. Levoixin is a hexagonal plate-like crystal; melting point 208.6°C, boiling point 210°C (779 mmHg), relative density 1.1011 (20/4°C), -37.74° (ethanol); soluble in ethanol, ether, acetone and benzene. Racemic ice flakes are leaf-like crystals; melting point 210.5°C, easily sublimed, relative density 1.011 (20/4°C); soluble in alcohol, ether and benzene. Camphor is generated when oxidized. Borneol can be reduced with camphor in sodium alcohol solution with sodium metal; or by limonene in the presence of a catalyst with oxalate and then hydrolyzed. Borneol is widely used in the preparation of rosemary and lavender flavors and is used in traditional Chinese medicine and Chinese ink.
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