The research results of Ocean University of China provide new ideas for eliminating drug-resistant bacteria

June 05, 2019 Source: Science Network

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Recently, Zhang Xiaohua, a professor at Ocean University of China, has made important progress in the field of microbial population behavior regulation and drug resistance research, revealing the dynamic regulation of signal molecules on bacterial antibiotic resistance, and providing new ideas for eliminating drug-resistant bacteria. The related paper "Indole reverses intrinsic antibiotic resistance by activating a novel dual-function importer" was published online in the microbiology authoritative journal mBio (Zone 1) by activating a novel dual-function pump to reverse bacterial intrinsic antibiotic resistance.

With the widespread use of antibiotics, more resistant bacteria have emerged in the marine environment, posing a serious threat to environmental protection and human health. Quercus is a widespread quorum sensing signal molecule involved in the regulation of various physiological behaviors between bacteria, such as antibiotic resistance, biofilm production and bacterial motility. Bacterial resistance mediated by signaling molecules is an emerging mechanism that has received much attention in recent years. As an interspecies signaling molecule, past studies have shown that it can enhance the antibiotic resistance of bacteria. However, whether sputum can inhibit bacterial antibiotic resistance is largely unknown.

In the previous study, the researchers first discovered that cockroaches can reverse the resistance of the enzyme-producing lysogen. In this paper, the researchers first reported the phenomenon of å²å“š-mediated reversal of antibiotic resistance in lysogens. This reversal is closely related to a novel BtuD bifunctional transporter that transports both vitamin B12 and antibiotics. It stimulates the overexpression of the btuD gene and promotes the efficient absorption of extracellular vitamin B12 by bacteria, but at the same time causes excessive intake of antibiotics by cells, resulting in cell death. The researchers further found that it is a ubiquitous phenomenon that alfalfa can inhibit the intrinsic antibiotic resistance of many different species of bacteria. Interestingly, the reversal of lysozyme antibiotic resistance can be restored by another quorum sensing signal factor, LeDSF.

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