It is generally believed that in living organisms, almost all organic biomolecules with important physiological significance have chirality, and most of them are optically active substances. A compound having the same chemical composition and molecular formula, but which is a mirror image due to the difference in the spatial orientation of the atoms constituting the compound, is called a chiral compound. Since the enantiomers have the same physical and chemical properties, it is difficult to achieve their separation. For example, most amino acids have a right-handed body and a left-handed body, but often only a mixture of a right-handed body and a left-handed body is obtained. Chiral drugs tend to exhibit one enantiomer with strong biological activity and efficacy, while the other is ineffective.
In recent years, the quantitative analysis of the separation of chiral drugs has been extensively studied. Among them, the separation and analysis of drug enantiomers in biological fluids is beneficial to understand the pharmacokinetics, metabolic processes and bioavailability of various enantiomers. Therefore, the resolution of the enantiomers of chiral drugs is also a hot spot in liquid chromatograph analysis. The chiral HPLC resolution method is based on the introduction of a chiral environment based on modern HPLC technology to separate the enantiomers from physical characteristics. The separation of enantiomers of chiral drugs by liquid chromatography can be divided into direct and indirect methods. The former introduces the asymmetric center into the molecule and can be divided into a chiral mobile phase additive (CMP) method and a chiral stationary phase (CSP) method; the latter is also called a chiral reagent derivatization (CDR) method, which is The asymmetric center is introduced into the molecule. Â Â
As a chiral reagent derivatization method, an enantiomer is derivatized by a chiral reagent to form a diastereomer, and then separated and measured by a conventional HPLC method. It is suitable for compounds that are not suitable for direct resolution, such as chiral fatty amines, alcohols, etc. The separation effect of the method is good, the separation conditions are simple, but the requirements of the chiral derivative reagent are high, the operation is troublesome, and it is often used when other methods cannot be realized. In the process of enantiomeric resolution in biological samples, due to the interference of endogenous substances and metabolites, analysis by liquid chromatography alone may cause overlapping of peaks and cannot directly analyze chiral drugs in vivo. At present, this type of problem has been successfully solved using multi-column coupling technology. Â Â
From the current point of view, HPLC is one of the most widely used methods for chiral drug separation. It is foreseeable that this method will be more widely used in future chiral drug research because of its fast, convenient and accurate characteristics. Applications.
If you have a liquid chromatograph related to chiral drug analysis, please call Shandong Luchuang Analytical Instrument Co., Ltd. hotline or visit the company's website http:// to consult the staff online.
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