Angelica on the role of uterine smooth muscle

Effect on uterine smooth muscle

1. Effect on isolated uterus Fuhua equaled 1954. It was reported that the two components of excitatory and inhibitory uterine smooth muscles in Jixian County of Gansu at the time were bidirectional. The inhibitory components are mainly volatile oils, and the excitatory components are water-soluble or alcohol-soluble and ether-insoluble non-volatile substances. In the same year, Wu Yijie et al. also reported that Angelica sinensis had different effects on isolated uterus and in vivo uterus, and decoction or ethanol extract had an inhibitory effect on isolated uterus (in vivo uterus, it was mainly excitatory). In the following year, Pi Xiping's experiments showed that liquor extracts and water extracts were inhibited after the first dose, and they were excited after flushing and recovery. Further studies showed that angelica volatile oil has a direct inhibitory effect on non-pregnant, early pregnancy, late pregnancy, and post-natal uterus of rabbits, guinea pigs, mice, rats, and dogs, and the rhythmic contraction gradually decreases to disappear. Relaxation. And against uterine contractions caused by pituitrin, histamine, epinephrine and acetylcholine. Angelica extract is mainly excited, high doses sometimes inhibited.

2. The role of the body in the uterus

Reports by Lv Fuhua and Pi Xiping showed that various preparations of angelica decoctions, tinctures, petroleum ether dip, and aqueous extracts are used for anesthesia, early pregnancy, late pregnancy, and postpartum of anesthetized dogs, cats, and rabbits. Body uterus is mainly excited. Slow iv decoction, a few inhibitory effect, when the removal of volatile oil after the slow iv is still significantly excited. This shows that Angelica volatile oil has the effect of inhibiting uterine muscle in the body. Japanese scholar Harada et al. reported that anesthetized rabbits (duodenum) were given Angelica sinensis (1g/kg), causing the uterus to contract first and then inhibit. After removing the fat-soluble portion of Angelica sinensis, the water-soluble portion (4 mg/kg) containing the active ingredient was iv anesthetized, causing the uterus to contract and the blood pressure to drop. Atropine can antagonize this reaction, so it may have cholinergic activity. Ozaki and others observed the effects of ferulic acid, an angelica component, on spontaneous motility in rat uterus. Amounts of 300-1000 mg/kg or 30-100 mg/kg iv inhibited uterine movement. Studies have also shown that Angelica sinensis strengthens the uterine muscle contraction when the intrauterine pressure is high, but this effect is absent when the intrauterine pressure is not high, so the pregnant woman bans the product. Ozaki Yukihiro et al.'s study demonstrated that the combination of po or iv ferulic acid and tetramethylpyrazine enhanced the inhibition of uterine contractions in situ in rats.

3. Effect on uterine fistula

Lv Fuhua et al. reported that po Angelica decoction is effective in suppressing the uterine fistulas of unsuspected adult rabbits. When the uterus is not pressurized, it is inhibited; if intrauterine pressure is applied, it is transformed by irregular, weak, and short-lying contractions. Become a regular and powerful contraction with extended intervals. However, intravenous Angelica tincture only has no obvious excitatory effect. The biphasic response to uterine smooth muscle in Angelica sinensis shows that the effect of Angelica sinensis is closely related to the functional state of the uterus. It regulates contraction of uterine smooth muscle and relieves phlegm to achieve the effect of regulating menstruation and analgesia.


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