[China Pharmaceutical Network Technology News] Dae-HyeongKim, an assistant professor at Seoul National University, was selected as the 2013 director of the MIT Technology Review magazine for his outstanding contribution to the use of stretchable materials for medical devices. Innovative figures of outstanding young people around the world. 
Gu Yu, assistant professor of the Department of Biomedical Engineering at the University of North Carolina's Chapel Hill School of Medicine, School of Pharmacy, North Carolina State University, was invented the "Intelligent Insulin Patch" by the MIT Technology Review. Selected as a global outstanding young talent in 2015.
These two young people from the Eastern world were 34 years old when they were selected as "outstanding young people in the world." Their leading research in the field of diabetes surveillance is highly regarded by journals such as Nature. If everything goes well, the health management of people with diabetes will be another story in the next 5 to 10 years.
Graphene wristbands that monitor and regulate blood sugar levels On March 21st, Nature and Nanotechnology magazine published the latest study by the Dae-HyeongKim team. The Kim team invented a graphene wristband that monitors and regulates blood sugar levels. .
This wristband consists of two parts, one of which is the blood glucose concentration monitoring area and the other part is the treatment area (controlling blood glucose concentration).
Hui Won Yun-Seoul National University
Graphene has the reputation of being the king of new materials. Due to its high toughness, high light transmittance and good electrical conductivity, it has received a lot of attention in many fields in recent years. The Kim team also wants to use this new material in the medical field. However, the inherent inertness of graphene materials, that is, the lack of electrochemical capability, has also plagued many researchers. Kim then creatively blended graphene with gold. This small change made graphene a sensor that can detect skin temperature and humidity, sweat pH and glucose concentration. Finally, the blood glucose concentration is comprehensively analyzed based on the temperature and humidity of the skin, the pH of the sweat, and the glucose concentration. And pass the data to the mobile device.
The left side is the monitoring area, and the right side is the treatment area. Once the blood glucose concentration exceeds the standard in the monitoring area, the heater located in the treatment area will activate the micro needle, melt the outer membrane of the drug storage body, and the micro needle will penetrate under the superficial skin. The hypoglycemic drug metformin is injected into the patient to achieve the purpose of controlling blood sugar. Of course, in order to avoid excessive hypoglycemic drugs injected into the human body, the melting of the meltable outer membrane on the surface of the needle in the treatment area is controlled in a time-sharing manner. The implication is that the fragments melt, and once the blood sugar is controlled, the melting stops. Ultimately achieve intelligent regulation of blood sugar concentration.
Can such a smart blood glucose management patch be available when it comes to market? I can't predict the exact time. But if you know that this device is jointly developed by the Kim team and MC10, a well-known flexible electronics company in Massachusetts, you will have more confidence in the time it will be available.
Smart insulin patch <br> <br> compared to Kim team combines a variety of high-tech, the final concentration of blood glucose monitoring through sweat wristband, Gu Zhen team of smart insulin patch will have a direct and more.
Smart insulin patch was named one of the top ten most beautiful pictures in 2015 by Science. The “smart insulin patch†developed by Gu Yu team only has the size of a fingernail, and the side of the patch is covered with 121 tiny needles. These needles are full of Tiny vesicles. When the blood glucose level is too high, these vesicles will open and release insulin.
Schematic diagram of the working principle of the patch On July 7, 2015, the research results of the Gu Yu team were published on the PNAS, and quickly made headlines of "Nature" and "Science". It’s a big trend to end the era of diabetes injection therapy.
The principle of this intelligent insulin patch by Gu Yu team is very simple, but the design is very clever. They cleverly use the chemical reaction process in the body to achieve the purpose of releasing insulin. They also put hypoglycemic insulin in the microneedles of the patch, but this insulin is also wrapped in a chemical. When the blood glucose level rises, the glucose entering the microneedle from the blood will chemically react in the microneedle, causing the insulin-encapsulated vesicle to rupture and release the insulin. When the blood glucose level is lowered, insulin stops releasing. It also skillfully achieves controllable insulin release.
When posting on the body, it is such a way to obtain a more continuous blood sugar regulation ability, Gu Yu team has made further improvements to this smart insulin patch. This time, they replaced the insulin in the patch directly with beta cells that produce insulin.
The green color of the patch is the islet cells, and the orange color is the glucose sensor. The transplantation of islet β cells is actually a treatment for diabetes. However, due to the rejection reaction of allogeneic transplantation, this method can not meet the needs of all people. . This method of Gu Yu team effectively avoids rejection (because immune cells are isolated). In February of this year, the research results of the Gu Yu team were published in the top journal “AdvancedMaterials†in the field of materials.
It is reported that the Gu Yu team is currently in contact with relevant companies to jointly develop this kind of smart patch.
Due to the large number of people with diabetes worldwide and the lack of very good management and treatment methods, academic and industrial circles are very enthusiastic about the development of diabetes management and treatment methods. The psychological needs of non-invasive testing and non-invasive management are also very high.
At present, similar research mainly stays in the pre-clinical animal experiment stage, and it is necessary to improve and optimize the experimental system in different body types of animals. If everything goes well, it will be clinically available in about two or three years, and commercialization in 5-10 years. Therefore, non-invasive diabetes management really goes into life, and you need to wait patiently.
Gu Yu, assistant professor of the Department of Biomedical Engineering at the University of North Carolina's Chapel Hill School of Medicine, School of Pharmacy, North Carolina State University, was invented the "Intelligent Insulin Patch" by the MIT Technology Review. Selected as a global outstanding young talent in 2015.
These two young people from the Eastern world were 34 years old when they were selected as "outstanding young people in the world." Their leading research in the field of diabetes surveillance is highly regarded by journals such as Nature. If everything goes well, the health management of people with diabetes will be another story in the next 5 to 10 years.
Graphene wristbands that monitor and regulate blood sugar levels On March 21st, Nature and Nanotechnology magazine published the latest study by the Dae-HyeongKim team. The Kim team invented a graphene wristband that monitors and regulates blood sugar levels. .
This wristband consists of two parts, one of which is the blood glucose concentration monitoring area and the other part is the treatment area (controlling blood glucose concentration).
Hui Won Yun-Seoul National University
Graphene has the reputation of being the king of new materials. Due to its high toughness, high light transmittance and good electrical conductivity, it has received a lot of attention in many fields in recent years. The Kim team also wants to use this new material in the medical field. However, the inherent inertness of graphene materials, that is, the lack of electrochemical capability, has also plagued many researchers. Kim then creatively blended graphene with gold. This small change made graphene a sensor that can detect skin temperature and humidity, sweat pH and glucose concentration. Finally, the blood glucose concentration is comprehensively analyzed based on the temperature and humidity of the skin, the pH of the sweat, and the glucose concentration. And pass the data to the mobile device.
The left side is the monitoring area, and the right side is the treatment area. Once the blood glucose concentration exceeds the standard in the monitoring area, the heater located in the treatment area will activate the micro needle, melt the outer membrane of the drug storage body, and the micro needle will penetrate under the superficial skin. The hypoglycemic drug metformin is injected into the patient to achieve the purpose of controlling blood sugar. Of course, in order to avoid excessive hypoglycemic drugs injected into the human body, the melting of the meltable outer membrane on the surface of the needle in the treatment area is controlled in a time-sharing manner. The implication is that the fragments melt, and once the blood sugar is controlled, the melting stops. Ultimately achieve intelligent regulation of blood sugar concentration.
Can such a smart blood glucose management patch be available when it comes to market? I can't predict the exact time. But if you know that this device is jointly developed by the Kim team and MC10, a well-known flexible electronics company in Massachusetts, you will have more confidence in the time it will be available.
Smart insulin patch <br> <br> compared to Kim team combines a variety of high-tech, the final concentration of blood glucose monitoring through sweat wristband, Gu Zhen team of smart insulin patch will have a direct and more.
Smart insulin patch was named one of the top ten most beautiful pictures in 2015 by Science. The “smart insulin patch†developed by Gu Yu team only has the size of a fingernail, and the side of the patch is covered with 121 tiny needles. These needles are full of Tiny vesicles. When the blood glucose level is too high, these vesicles will open and release insulin.
Schematic diagram of the working principle of the patch On July 7, 2015, the research results of the Gu Yu team were published on the PNAS, and quickly made headlines of "Nature" and "Science". It’s a big trend to end the era of diabetes injection therapy.
The principle of this intelligent insulin patch by Gu Yu team is very simple, but the design is very clever. They cleverly use the chemical reaction process in the body to achieve the purpose of releasing insulin. They also put hypoglycemic insulin in the microneedles of the patch, but this insulin is also wrapped in a chemical. When the blood glucose level rises, the glucose entering the microneedle from the blood will chemically react in the microneedle, causing the insulin-encapsulated vesicle to rupture and release the insulin. When the blood glucose level is lowered, insulin stops releasing. It also skillfully achieves controllable insulin release.
When posting on the body, it is such a way to obtain a more continuous blood sugar regulation ability, Gu Yu team has made further improvements to this smart insulin patch. This time, they replaced the insulin in the patch directly with beta cells that produce insulin.
The green color of the patch is the islet cells, and the orange color is the glucose sensor. The transplantation of islet β cells is actually a treatment for diabetes. However, due to the rejection reaction of allogeneic transplantation, this method can not meet the needs of all people. . This method of Gu Yu team effectively avoids rejection (because immune cells are isolated). In February of this year, the research results of the Gu Yu team were published in the top journal “AdvancedMaterials†in the field of materials.
It is reported that the Gu Yu team is currently in contact with relevant companies to jointly develop this kind of smart patch.
Due to the large number of people with diabetes worldwide and the lack of very good management and treatment methods, academic and industrial circles are very enthusiastic about the development of diabetes management and treatment methods. The psychological needs of non-invasive testing and non-invasive management are also very high.
At present, similar research mainly stays in the pre-clinical animal experiment stage, and it is necessary to improve and optimize the experimental system in different body types of animals. If everything goes well, it will be clinically available in about two or three years, and commercialization in 5-10 years. Therefore, non-invasive diabetes management really goes into life, and you need to wait patiently.
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