Release date: 2017-05-02
Smartphones are playing an increasingly important role in our daily lives – the first thing many people do after blinking is to take a lap of the phone and see what happens next to them. What happens if we can use these smartphones for medical health? Today, Professor Ye Haifeng from Shanghai East China Normal University brought a heavy invention. Using a combination of mobile phones and optogenetics, the researchers can manipulate cells in diabetic mice to secrete glucagon-like peptide 1 or insulin, which stabilizes blood sugar levels.
This heavyweight discovery was published on the cover of the latest issue of Science Translational Medicine. 
Smartphones are playing an increasingly important role in our daily lives – the first thing many people do after blinking is to take a lap of the phone and see what happens next to them. What happens if we can use these smartphones for medical health? Today, Professor Ye Haifeng from Shanghai East China Normal University brought a heavy invention. Using a combination of mobile phones and optogenetics, the researchers can manipulate cells in diabetic mice to secrete glucagon-like peptide 1 or insulin, which stabilizes blood sugar levels.
This heavyweight discovery was published on the cover of the latest issue of Science Translational Medicine. 
â–² Professor Ye Haifeng (front row, right one) project portfolio (Source: Shanghai Key Laboratory of Regulatory Biology)
To answer this question, the researchers first developed a cell that can be regulated by light. These cells activate specific genes under the illumination of far-infrared light that is harmless to the human body. In the previous experiments, the researchers confirmed that these cells only responded to far-infrared light, and the stronger the illumination, the longer the illumination time, the more obvious the effect of these genes. 
â–²The stronger the light (left), the longer the illumination time (right), the more active the genes in these cells (Source: Science Translational Medicine)
Subsequently, the researchers gave these cells a gene that secretes insulin or glucagon-like peptide-1, and then designed a special gel. In addition to these cells, the gel also has a Bluetooth signal receiver and LED lights that emit far-infrared light. The researchers envisioned that after using the mobile phone to give instructions, the Bluetooth signal receiver could activate the far-infrared LED to illuminate these modified cells, allowing these cells to secrete hormones that lower blood sugar, thereby controlling the blood sugar of the animal.
After implanting these gels into the body of diabetic mice, the researchers' ideas were confirmed! Experiments show that this gel can not only be stable in mice, but also rely on the control of the mobile phone to secrete hormones that control blood sugar. In addition, these glycemic control effects can last for several weeks. This has undoubtedly opened up a new way for the treatment of diabetes. 
â–²The cells implanted in the mouse can effectively promote hormone secretion (left) and lower blood sugar (right) under the control of mobile phones (Source: Science Translational Medicine)
Although the application is only a prototype, the researchers believe that it will have a bright future. If the conditions of the regulatory authorities are met, the mobile phone system for treating diabetes is expected to be marketed as a new type of cell therapy for the benefit of patients. “This will bring an era of precision medicine that is individualized, digital, and global.†Professor Ye Haifeng’s team said at the end of the paper.
Imagine that when the day comes true, people with diabetes can simply take out their mobile phones and tap the screen to enjoy food and life like a healthy person. This will be a picture full of technology and humanity. We look forward to the early arrival of this day.
Source: Health New Vision
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