Two papers published online by Nature's Icahn School in Mount Sinai and Regensburg University in Germany on December 15 revealed that breast cancer cells with certain molecular changes can spread to other organs even before the primary tumor is formed. Stay silent for a long time and then wake up to form an aggressive, fatal breast cancer metastasis.
The researchers said that their findings in Nature were obtained by conducting experiments in animal models and testing them in human samples. These findings address the secrets of how metastatic breast cancer develops in the absence of primary tumors in this new early tumor transmission and metastasis model. Even researchers say that clinically primary tumors may never form. Both teams have now identified mechanisms that allow cells to spread early in cancer progression and promote metastasis.
1, the Sinai team found that breast cancer can be transferred without primary tumor
In the Sinai study, two changes in breast cancer cells (an open oncogene and a closed tumor suppressor gene) prompted cells to migrate from the breast tissue to the lungs and other parts of the body. There, the cells remain stationary until the growth switch is activated and metastases appear in the lungs.
Corresponding author of the study, Julio A. of Mount Sinai. Dr. Aguirre-Ghiso said: "This study provides insight into the mechanisms of early cancer transmission and may shed light on some unknown causes: why up to 5% of cancer patients worldwide have no primary tumors Cancer cells spread? The most important thing is why this early-spreading cancer is so difficult to treat. Biologically, this new pattern of early metastasis challenges what we know about how cancer spreads and forms metastases. We will I have to adjust our thoughts on the topic of tumor metastasis, and we hope that these findings will reshape the way we think about how to treat tumor metastasis."
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