Maduramycin is a monovalent glycoside polyether ion carrier antibiotics, mainly used for the prevention and treatment of chicken coccidiosis, has a wide spectrum of high efficiency, low resistance, no residue, etc., widely used, but its amount is very small, safe The scope is very narrow. The recommended dosage is very close to the toxic dose. Individual farmers and veterinarians lack the correct understanding of this drug. When the spherocytosis is controlled, it is often used twice, causing chicken poisoning and causing unnecessary economic losses.
Incidence
A farmer breeds 3,300 2-month-old laying hens and raises them in two broiler houses. Only a few chickens can pull blood. On an individual veterinarian's instruction, Maduramycin was started in the feed on March 12, 2007, and 15 tons of Maduramycin was added to a 1.5-ton feed at a concentration of 10 ppm. About one-half day after feeding, about half of the chickens had snoring, no food, and phlegm. The livestock owner saw serious problems and immediately went to the Bureau of Animal Husbandry in Qing County, Hebei Province, and was diagnosed as Maduramycin poisoning. After taking a series of comprehensive measures, the chicken symptoms eased the next day. On the third day, the individual veterinarian sent a bag of glucose and VC. One of the houses increased the amount of VC. 400 kg of feed and 500 kg of water were added with 1 kg of 99% VC, respectively. The excess was 7 times. The result was the fourth day. The chickens once again showed symptoms such as lack of energy, and immediately stopped feeding VC. One week later, the flock returned to normal, with a total of 56 deaths and a drug fee of a thousand dollars.
Pathological changes
The author dissected 10 diseased chickens. The diseased chickens had no obvious characteristic lesions. The diseased chicken showed hepatomegaly, blood stasis, purple; gallbladder swollen, full of bile; splenomegaly 2 times, dark purple; diffuse bleeding intestinal mucosa, especially severe duodenal bleeding, cecal tonsil swelling, individual Streaked hemorrhage was found at the junction of the stomach and glands of the chicken muscle; kidney swelling was bleeding.
Microbiological examination
Sterilely take the diseased chicken heart, liver, spleen, kidney and other organ tissue smears, after dry naturally after Wright's staining microscopic examination, no suspicious bacteria were found. The above materials were inoculated on MacConkey medium and common nutrient medium, and cultured in a constant temperature incubator at 37°C for 24 hours without any colony growth.
diagnosis
According to the clinical symptoms, necropsy changes, microbiological examination and drug history, it was diagnosed as Madura toxin.
treatment
Immediately stop feed containing Maduramycin, supply sufficient water, and mix drinking water with 5% dextrose and 0.1% VC to improve the body's resistance to disease and detoxification. Alternately use 0.2% of kidney detoxification spirit , Even drink 3 days, severe intramuscular injection of vitamin C injection; feed supplemented with disease-resistant blended amino-vitamin; Chinese medicine licorice can be detoxified, according to each chicken 1 g ~ 2 grams, boiled soup drink, use 3 days. The condition improved on the second day and he recovered after one week.
Experience and precautions
Maduramycin is effective in controlling and killing coccidia and can directly destroy the balance of sodium and potassium ions in the coccidia, killing coccidia, but at high concentrations it kills the body's cells. Its use dose and poisoning amount are very close, and the mixed feeding dose is 5ppm. If it exceeds 6.5ppm, it is easy to cause poisoning. Therefore, the dosage should be strictly controlled when using it. At the same time, the continuous medication should not exceed 5 days.
Although vitamin C is a nutritive substance, it has the functions of anti-oxidation, immunity enhancement, detoxification, etc., but overuse can cause adverse reactions. According to its description or pharmacopoeia, it must not be used arbitrarily.
When using Maduramycin to prevent coccidia, special attention should be paid, and the medicine must be mixed evenly. The specific method is to first mix the medicine with a small amount of feed in the pot, then mix it gradually with a large amount of feed, and finally stir it repeatedly 7 times to 8 times.
After feeding chicken maduramycin, the feces must not be used as feed for other animals to prevent mold in other animals.
Before using the drug, it is firstly ascertained whether the amount of Maduramycin and its additives has been added to the used feed to avoid repeated drug use.
When using water-soluble Maduramycin to drink water, factors such as the large amount of drinking water in the summer should be considered, and the total amount of controlled use should not exceed the standard to avoid poisoning.
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