With the introduction of high-throughput sequencing technology and the improvement of "big data" processing capabilities, modern medicine is undergoing tremendous changes, from the traditional standardized medical model to the individualized medical model. The completion of the Human Genome Project and the encyclopedia of DNA elements and the mapping of tumor gene maps also provide a powerful tool for the “specialized medicine†type of personalized medicine, and the medical field faces new opportunities. However, industry insiders said that despite the considerable market space, in the short term, personalized medical-related technologies and products have limited contribution to the income of related companies.
New advances in medicine
In general, everyone's response to drugs varies. However, when pharmaceutical companies develop drugs and doctors prescribe, technical limits are usually only available for the average of most patients.
For example, in the United States, 100,000 new patients with colorectal cancer are added each year, and the drug for colorectal cancer, Erbitux, is more effective for patients with the wild type gene of Kras; if the patient carries the Kras mutant gene, the effect is Will drop sharply. The proportion of Kras wild-type genes in patients is about 60%, and the duration of a course of love is more than $50,000. A Kras detection technology developed by Kaiser, Germany, can determine whether a patient is eligible for Erbitux treatment for only $300. This story reflects the importance of “personal treatment†for personalized medicine.
Individualized medical treatment is based on the individual's genomic information, combined with proteomics, metabolomes and other related internal environmental information, to design a treatment plan for patients, in order to achieve a customized treatment model to maximize treatment effect and minimize side effects. Compared with traditional medical treatment, individualized medical treatment is characterized by specificity, efficiency and preventiveness. The United States is actively promoting individualized medical care. Recently, US President Barack Obama announced in his State of the Union address a personalized medical plan with a budget of $215 million.
Judging from the mortality rate in China, the mortality rate of major diseases has shown a significant upward trend in recent years. In 2006, the results of a sample survey of the third cause of death in China showed that breast cancer mortality increased by 96% in 30 years, and lung cancer mortality was even more than 465%. According to the World Cancer Report, the number of cancers in China in 2012 was 3.065 million, accounting for about one-fifth of the global incidence; the number of cancer deaths was 2.205 million, accounting for about a quarter of the global cancer deaths.
On the one hand, the treatment of such malignant diseases is to increase the breakthrough of research and development of therapeutic drugs, and on the other hand, to break through the treatment technology from the perspective of individualized treatment. Professionals pointed out that with genetic diagnosis, medical care will progress from the era of "mass medical" to the "customized medical" era that varies according to individual genetics. Individualized medical treatment traces the origin of the disease, not only needs to find the cause, but also traces the cause to the molecular level, based on which the patient is treated. This standardization of the diagnosis and treatment process reflects the individual differences of patients and is a new height in the development of modern medicine.
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