Release date: 2015-01-12
Japanese researchers have recently developed an antibody that reduces abnormal Tau protein in the brain that causes Alzheimer's disease (Alzheimer's disease) and has successfully improved the memory of experimental mice. This will help develop drugs to treat Alzheimer's disease.
Related studies have shown that there are two pathological changes in the brain of Alzheimer's patients, one of which is the hyperphosphorylation of Tau protein, which will accumulate in the cells to form neurofibrillary tangles, neurofibrillary tangles It is closely related to neuronal cell death and cognitive dysfunction.
The research team at Osaka City University developed an antibody that can be combined with phosphorylated Tau protein and was injected once a week with about 10 mg of Tau protein abnormalities in the brain. The results were successfully reduced. Abnormal Tau protein in the rat brain prevents the death of nerve cells.
To investigate the memory of the experimental rats, the researchers allowed the rats to swim in the labyrinth pool. As a result, it was found that the average time of a group in which the antibody was injected was only about half that of the group not injected with the antibody. The team confirmed that the injection of this antibody has the effect of improving the memory of the diseased mice.
Related papers have been published in the online edition of the American Journal of Clinical and Translational Neurology.
Source: China Science and Technology Network - Technology Daily
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