Release date: 2017-02-07
       
Image source: medicalxpress.com
Recently, a research report published in the international magazine PLOS ONE , researchers from Yale University and other institutions found that melanoma cells can fuse with white blood cells to form a metastatic hybrid, the relevant research may be late Researchers have shed light on how melanoma and other cancers spread from solid tumors.
When melanoma cells spread from primary tumor sites to other organs and tissues, they have a certain lethal effect. Based on the theory proposed in previous studies, the researchers in this paper tested the molecules that spread cancer cells from solid tumors through joint research. mechanism. The researchers studied patients with bone marrow transplants before melanoma and analyzed tumor biopsies from the patient's body. The researchers then placed primary melanoma sites and melanoma cells that spread to the lymph nodes. DNA was analyzed and researchers at both sites discovered a DNA mixture between the patient and the donor.
Researcher Pawelek said that the presence of patient-donor mixed DNA indicates that white blood cells that normally attack cancer cells fuse with cancer to form a hybrid that promotes the spread of cancer cells, and the DNA of cancer cells and white blood cells can be mixed into it. In the same nucleus, the hybrid not only has the characteristics that white blood cells can move into the lymph nodes, but also has the characteristics that the primary tumors are constantly dividing.
The current findings confirm the findings of researchers in 2013, when researchers detected the presence of hybrid cells in the body of patients with metastatic melanoma who underwent bone marrow transplantation, and studies of bone marrow transplant patients could help researchers effectively differentiate cells. The source of DNA; the researchers believe that this new type of fusion cell may be a new target to help develop new therapies for the treatment of melanoma, and now they need to focus on how melanoma cells fuse with white blood cells, of course It involves multiple processes; new therapies developed by future researchers will not only inhibit cell fusion from the bone marrow, but also limit the integration of fusion genes into hybrids, and the signal pathways of current researchers may help them develop new targets. New technology for cancer metastasis.
Source: Bio Valley
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