Pharmacological effects
1. Experiments on the cardiovascular system showed that: The volatile oil of shank pepper intravenously injected into dogs can significantly reduce myocardial oxygen consumption and arterial pressure without affecting coronary flow, coronary resistance and central venous pressure. It can also counteract the effect of pituitrin on reducing coronary artery flow in isolated rabbit hearts. Volatile oil 0.3ml/kg/d was intragastrically administered to rabbits for 3 consecutive days to reduce ST elevation in acute myocardial ischemia caused by double ligation of the left anterior descending coronary artery, reduce the number of pathological Q waves and the percentage of myocardial infarction, and reduce blood dissociation. Fatty acid levels. For isoprenaline-induced experimental myocardial infarction in rats, volatile oil can reduce the total ST-segment downshift, prevent the occurrence of Q waves and reduce the incidence of severe arrhythmia. It has been reported that citral is an effective component of anti-myocardial ischemia. Citralin can improve the electrocardiogram of experimental myocardial ischemia induced by pituitrin or isoproterenol in rabbits. Significantly increased coronary artery flow in isolated rabbit hearts, relaxation of isolated porcine coronary artery and anti-adrenergic and high K+ contraction of coronary artery, can also inhibit norepinephrine-induced intracellular calcium contraction and extracellular calcium Sexual contraction.
The volatile oil of C. solanacearum can significantly reduce the incidence of ventricular fibrillation in mice caused by chloroform, and cause sinus rhythm of bidirectional tachycardia induced by cesium chloride in rats. However, it can not improve ouaba. Causes arrhythmia and lethal dose in rats caused by guinea pigs and aconitine. Citral administration to rats could significantly shorten the duration of arrhythmia induced by strontium chloride, prolong the latency of arrhythmia induced by aconitine, and reduce the rate of rat ventricular fibrillation induced by calcium chloride. Mortality increased the lethal dose of digoxin poisoning in rabbits, but it could not increase the threshold of rabbit ventricular fibrillation induced by electrical stimulation.
Shankejia volatile oil intravenous injection, can reduce arterial pressure in dogs; inhibition of cat myocardial contractility and slow heart rate. Citral is administered intravenously to anesthetized cats to reduce blood pressure and slow heart rate. Can still fight adrenaline-induced vasoconstriction.
2. The effect of the digestive system on the intragastric administration of jackbumin extract and water extract to rats can significantly inhibit hydrochloric acid-induced gastric ulcers; ether extracts are given to mice by gavage, and there are also water-soaked stress ulcers. Counteraction. Ether extract and water extract gavage the mice against senna or castor oil-induced diarrhea in mice and inhibit mouse ink in the gastrointestinal tract. Water decoction has inhibitory effect on the activity of isolated intestine, and can resist the activity of isolated intestine of acetylcholine, physostigmine, nicotine, histamine, strontium chloride, phentolamine, etc. Ether extracts and water extracts were intragastrically administered to rats, which had a markedly beneficial effect on gallbladder and caused a significant increase in bile secretion.
3. The role of the respiratory system Shanjia pepper volatile oil on acetylcholine-induced wheezing has a significant protection; guinea pig smooth muscle and acetylcholine or histamine-induced tracheal smooth muscle contraction, there is a significant relaxation effect, this effect can not be propranolol Blocking. It has been reported that the intraperitoneal injection of volatile oil to mice can significantly prolong the cough latency, but there are also reports that there is no prolonged effect. Volatile oil has a blemish effect. Citral inhalation can increase respiratory fluid output in rabbits.
4. Other effects Shanjia pepper volatile oil (1:3 200) has inhibitory effects on Staphylococcus aureus, Salmonella typhi, Escherichia coli, and Shigella.
Decocted water decoction can inhibit the writhing response of mice induced by bismuth potassium tartrate and prolong the thermal pain reaction time; ether extract can significantly inhibit the acetic acid-induced writhing response of mice; water extract can significantly prolong the mouse's heat The latency of the stimulus response.
C. cannabinoid essential oil can reduce the incidence of anaphylactic shock in guinea pigs caused by egg white and prolong the convulsive latency; can inhibit the passive cutaneous anaphylaxis caused by egg albumin and trichosanthin antiserum; and inhibit the allergic contraction and slow response of isolated ileum in egg white sensitized guinea pigs Caused contraction of the ileum.
The fruit of Cubetona has local irritative effect on mucous membrane and can be absorbed. It also has effects on urinary tract and respiratory mucosa. Oral volatile oil has some antiseptic effect on the urinary tract. The effect of cubeplant is mainly caused by Cabaldine.
Shan Jijiao extract 1g/kg to the rabbit oral, can increase urine output and chloride excretion, and oral decoction or flow extract 2g/kg has no effect.
The 5% water extract of sage pepper can kill larvae of Culex pipiens pallens. The oil agent or glycerin rubs on the skin to avoid mosquitoes.
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