The pharmacological effects of honeysuckle

Honeysuckle is a collective name for Chinese herbal medicines and plants. The plant honeysuckle, also known as honeysuckle, is a perennial semi-evergreen winding lianas of the honeysuckle family. "Honeysuckle" comes from the "Compendium of Materia Medica", because the honeysuckle flower is initially white, and then turns yellow, hence the name honeysuckle. Medicinal material Honeysuckle is honeysuckle (Lonicera) Lonicera (Lonicera) and dried buds of plants of the genus Honeysuckle, or flowers of the beginning. Honeysuckle has been hailed as a good medicine for heat and detoxification.

Pharmacological effects 1, the role of anti-pathogenic microorganisms: In vitro experiments show that flowers and vines against a variety of pathogenic bacteria such as Staphylococcus aureus, hemolytic streptococcus, Escherichia coli, Shigella, Vibrio cholerae, Salmonella typhi, paratyphoid bacillus All have a certain inhibitory effect, and they are also effective against pneumococcus, meningococcus, Pseudomonas aeruginosa and Mycobacterium tuberculosis. The water infusion has a stronger effect than the decoction, and the leaf decoction has a stronger effect than the flower decoction. If combined with Forsythia, antibacterial range can also be complementary; combined with penicillin can enhance the antibacterial effect of penicillin on resistant Staphylococcus aureus, which may be a synergistic effect in the inhibition of protein synthesis in vivo.

2, anti-inflammatory and antipyretic effects: intraperitoneal injection of honeysuckle extract 0.25g/kg, can inhibit rat carrageenan leg swelling. Another report that honeysuckle injection 30 ~ 40g/kg can reduce egg white sexual swelling. Intraperitoneal injection of honeysuckle extract 8g/kg, 2 times / day, for 6 consecutive days, the croton oil granulocyst in rats, there is also significant anti-bleeding and anti-proliferative effect. Early reports that honeysuckle has a significant antipyretic effect, but with the cholera vaccine, potato bacillus, subtilis immersion liquid, etc. to the rabbit ear vein injection, fever, did not confirm the honeysuckle decoction 5g/kg intragastric antipyretic effect that this It may be related to different honeysuckle preparations used, dosage or rabbit tolerance.

3, to strengthen the immune function: honeysuckle decoction diluted to 1:1280 concentration, can still promote leukocyte phagocytosis. Intraperitoneal injection of honeysuckle injection also significantly promoted the phagocytic function of inflammatory cells.

4, the central stimulant: by electric shock, transfer cage and other experimental methods to prove that oral chlorogenic acid, can cause rats, mice and other animals central nervous system excitement, the role of the intensity of caffeine for the 1/6, 2 The combination of non-adding and enhancing effect.

5, lipid-lowering effect: rat oral honeysuckle 2.5g/kg can reduce intestinal cholesterol absorption, lower plasma cholesterol levels. In vitro experiments also found that honeysuckle can be combined with cholesterol, but Simiao Yongan Decoction (Honeysuckle, Scrophularia, Angelica, Licorice) was used to treat experimental atherosclerosis in rabbits. No hypolipidemic and aortic wall cholesterol levels were observed.

6. Anti-endotoxin: The endotoxin content was determined by the limulus test method. 300% honeysuckle (Lonicera) injection was diluted 1:2 to 1:64. In vitro tests were significantly reduced in the test solution whether they were used in the concave or in vitro test. The endotoxin content of the 1:2 to 1:8 dilution tube was the same as that of the negative control tube, and the positive control was gel-like. Honeysuckle (Lonicera) distillate 6g/kg intravenous injection of Pseudomonas aeruginosa poisoning each other 2.8mg/kg intravenous injection of rabbits caused by temperature decline and white blood cell count have a confrontational effect, honeysuckle (Lonicera) distillate 7.5g/kg or injection 2.5g/kg intraperitoneal injection of the liquid, Pseudomonas aeruginosa endotoxin 65mg/kg intraperitoneal injection of mice have a protective effect, reduce the mortality of mice.

7. Other effects: There have been in vitro screening experiments with water and wine extracts of honeysuckle having significant cytotoxic effects on sarcoma 180 and Ehrlich ascites carcinoma. The honeysuckle extract has a mild preventive effect on experimental gastric ulcers in rats. Oral high-dose chlorogenic acid can increase gastrointestinal motility and promote secretion of gastric juice and bile. Chlorogenic acid and its breakdown products have excitatory effects on isolated rat uterus. In addition, chlorogenic acid slightly increased the pressor effect of epinephrine and its norepinephrine on cats and rats, but had no effect on the cat's nictitating membrane reaction.